NCT06494215 Comparison of Different Methods to Calculate Pendelluft by Electrical Impedance Tomography in Mechanically Ventilated Patients
| NCT ID | NCT06494215 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Sao Paulo General Hospital |
| Condition | Asynchrony, Patient-Ventilator |
| Study Type | INTERVENTIONAL |
| Enrollment | 15 participants |
| Start Date | 2024-06-11 |
| Primary Completion | 2025-06-11 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 15 participants in total. It began in 2024-06-11 with a primary completion date of 2025-06-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The Pendelluft phenomenon is an important cause of lung damage in spontaneously breathing mechanically ventilated patients since it considerably increases the stress on the lung parenchyma in the dependent areas. It can result in a local driving pressure up to three times higher than the global driving pressure. The measurement of Pendelluft is still uncertain in the literature, and although various methods have been proposed, not all have the same meaning in terms of pulmonary overstress and overstrain. This study proposes a comparative analysis of different ways to calculate and estimate the stress imposed on the lung parenchyma by Pendelluft in terms of regional volume and local driving pressure through electrical impedance tomography.
Eligibility Criteria
Inclusion Criteria: * Patients under invasive mechanical ventilation intubated due to respiratory failure in pressure support mode (weaning phase) Exclusion Criteria: * Age less than 18 years; sedation or neuromuscular blockade; absence of respiratory effort; contraindications to esophageal balloon cathether positioning or electrical impedance tomography belt positioning; presence of pneumothorax or active air leaks; hemodynamic instability; absence of informed consent.
Contact & Investigator
Marcelo BP Amato
PRINCIPAL INVESTIGATOR
University of Sao Paulo General Hospital
Frequently Asked Questions
Who can join the NCT06494215 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Asynchrony, Patient-Ventilator. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06494215 currently recruiting?
Yes, NCT06494215 is actively recruiting participants. Contact the research team at marcelo.amato@hc.fm.usp.br for enrollment information.
Where is the NCT06494215 trial being conducted?
This trial is being conducted at São Paulo, Brazil.
Who is sponsoring the NCT06494215 clinical trial?
NCT06494215 is sponsored by University of Sao Paulo General Hospital. The principal investigator is Marcelo BP Amato at University of Sao Paulo General Hospital. The trial plans to enroll 15 participants.