Trial Parameters
Condition Pain, Postoperative
Sponsor Mayo Clinic
Study Type INTERVENTIONAL
Phase Phase 4
Enrollment 100
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2026-01-13
Completion 2026-06-30
All Conditions
Interventions
Methadone, oralMethadone, intravenously
Brief Summary
The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.
Eligibility Criteria
Inclusion Criteria: • Undergoing elective cardiac surgery Exclusion Criteria: * Chronic pain requiring opioid medications as an outpatient * Opioid use disorder on medication assistance treatment * Prolonged QTc \>500ms * Chronic kidney disease with eGFR \< 30mL/min * Documented cirrhosis * Intolerance to methadone * Admitted inpatient in an intensive care unit (ICU) immediately prior to surgery * Pregnancy at the time of surgery * Subsequent surgeries after index surgery
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