NCT07513844 Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease
| NCT ID | NCT07513844 |
| Status | Recruiting |
| Phase | — |
| Sponsor | First Affiliated Hospital of Fujian Medical University |
| Condition | Huntington Disease |
| Study Type | INTERVENTIONAL |
| Enrollment | 24 participants |
| Start Date | 2026-04-20 |
| Primary Completion | 2026-10-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 24 participants in total. It began in 2026-04-20 with a primary completion date of 2026-10-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this research study is to determine the optimal pulse repetition frequency of low-intensity focused ultrasound that is safe and effective in improving motor symptoms in patients with Huntington's disease.
Eligibility Criteria
Inclusion Criteria: 1. Aged 18 to 75 years (inclusive) 2. Genetically confirmed Huntington's disease with HTT CAG repeat length of 40 or greater 3. Unified Huntington's Disease Rating Scale Total Maximal Chorea score of 8 or higher on a scale of 0 to 28, with higher scores indicating more severe chorea 4. Huntington's Disease Integrated Staging System stage 2 or 3 5. Willing to participate and provide informed consent 6. Have a reliable caregiver available 7. No severe cognitive impairment that would preclude reliable reporting of adverse events or efficacy during treatment Exclusion Criteria: 1. History of self-injury, aggressive behavior, or unstable psychiatric disorders 2. History of head injury or neurosurgical procedure 3. Presence of intracranial implants, metallic foreign bodies, cochlear implants, or cardiac pacemakers 4. Severe systemic disease, pregnancy, or breastfeeding 5. Contraindications to magnetic resonance imaging, ultrasound, or anesthesia 6. Prior treatment with electroconvulsive therapy, transcranial magnetic stimulation, transcranial direct current stimulation, transcranial alternating current stimulation, or other neuromodulation therapies within the past 3 years 7. Severe brain atrophy with unclear external globus pallidus structure on MRI 8. Concurrent participation in another interventional clinical trial 9. Any other condition that, in the opinion of the investigator, would preclude participation
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07513844 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Huntington Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07513844 currently recruiting?
Yes, NCT07513844 is actively recruiting participants. Contact the research team at fychenxinyuan@fjmu.edu.cn for enrollment information.
Where is the NCT07513844 trial being conducted?
This trial is being conducted at Fuzhou, China.
Who is sponsoring the NCT07513844 clinical trial?
NCT07513844 is sponsored by First Affiliated Hospital of Fujian Medical University. The trial plans to enroll 24 participants.