NCT07332234 Optic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral Pathologies
| NCT ID | NCT07332234 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș" |
| Condition | Meningitis |
| Study Type | OBSERVATIONAL |
| Enrollment | 200 participants |
| Start Date | 2025-12-01 |
| Primary Completion | 2027-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 200 participants in total. It began in 2025-12-01 with a primary completion date of 2027-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Timely detection of signs of raised intracranial pressure or persistent inflammation within the meninges can expedite therapeutic decisions improving the prognosis of patients with brain damage. Optic nerve ultrasonography provides a user-friendly, safe, low-cost, and non-invasive imaging method that can be easily deployed for ICU patient assessment. This study aims to evaluate the sensitivity and specificity of optic nerve ultrasound in estimating cerebral inflammation extension and cerebral edema in patients in the ICU. The working hypothesis is that optic nerve ultrasound is a useful tool in the rapid diagnosis of cerebral edema and the presence or persistence of cerebral inflammation, which can enable adapted and rapid therapeutic interventions.
Eligibility Criteria
Inclusion Criteria: * Patients admitted into one of the specified wards of the involved hospitals * Patients aged 18-60 years * Suspected meningitis, encephalitis, stroke or cerebral tumors Exclusion Criteria: * Age under 18 years or over 60 years old * Ocular lesions preventing ocular ultrasound (palpebral infections, cornean erosions, glaucoma, trauma) * Conditions preventing lumbar puncture (coagulation disorders, epidural abscesses, local infections)
Contact & Investigator
Bogdan Pavel, MD, PhD, DESA
PRINCIPAL INVESTIGATOR
"Dr. Victor Babeș" Clinical Hospital for Infectious and Tropical Diseases
Frequently Asked Questions
Who can join the NCT07332234 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Meningitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07332234 currently recruiting?
Yes, NCT07332234 is actively recruiting participants. Contact the research team at bogdan.pavel@umfcd.ro for enrollment information.
Where is the NCT07332234 trial being conducted?
This trial is being conducted at Bucharest, Romania, Bucharest, Romania.
Who is sponsoring the NCT07332234 clinical trial?
NCT07332234 is sponsored by Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș". The principal investigator is Bogdan Pavel, MD, PhD, DESA at "Dr. Victor Babeș" Clinical Hospital for Infectious and Tropical Diseases. The trial plans to enroll 200 participants.