NCT07807696 Olive Oil Before Lung Cancer Surgery to Prevent Chylothorax
| NCT ID | NCT07807696 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Fudan University |
| Condition | Lung Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 1,036 participants |
| Start Date | 2026-03-15 |
| Primary Completion | 2027-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 1,036 participants in total. It began in 2026-03-15 with a primary completion date of 2027-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Chylothorax is a rare but serious complication after lung cancer surgery and mediastinal lymph node dissection. This multicenter randomized trial will evaluate whether drinking 40 mL of extra-virgin olive oil 4 hours before surgery can reduce the occurrence of chylothorax after curative lung cancer resection. A total of 1,036 adults with resectable lung cancer will be assigned in a 1:1 ratio to preoperative oral olive oil or standard preoperative fasting without additional olive oil. The primary outcome is the occurrence of chylothorax within 30 days after surgery. Secondary outcomes include repeat surgery, postoperative complications, chest drainage, length of chest tube use, length of hospital stay, and the safety and tolerability of the intervention.
Eligibility Criteria
Inclusion Criteria: * Voluntary participation and willing and able to complete all study procedures. * Age 18 to 80 years, inclusive, at informed consent. * Eastern Cooperative Oncology Group performance status of 0 or 1. * Resectable lung cancer. * No prior surgery for lung cancer. * Treatment-naive and no prior radiotherapy or chemotherapy. * Able to take food orally before surgery. Exclusion Criteria: * Allergy to olive oil or any of its components. * History of acute or chronic pancreatitis or severe biliary disease. * Fat malabsorption syndrome. * Prior ipsilateral thoracic surgery or thoracic radiotherapy or chemotherapy. * Unable to comply with preoperative dietary instructions.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07807696 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Lung Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07807696 currently recruiting?
Yes, NCT07807696 is actively recruiting participants. Contact the research team at 16301050173@fudan.edu.cn for enrollment information.
Where is the NCT07807696 trial being conducted?
This trial is being conducted at Shanghai, China.
Who is sponsoring the NCT07807696 clinical trial?
NCT07807696 is sponsored by Fudan University. The trial plans to enroll 1,036 participants.
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