NCT06088758 Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
| NCT ID | NCT06088758 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Massachusetts General Hospital |
| Condition | Liver Transplant |
| Study Type | INTERVENTIONAL |
| Enrollment | 200 participants |
| Start Date | 2024-02-28 |
| Primary Completion | 2026-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 200 participants in total. It began in 2024-02-28 with a primary completion date of 2026-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.
Eligibility Criteria
Inclusion Criteria: * Age 18-80 years * Listed for liver transplantation at MGH * Calculated MELD-Na score \<= 25 * Able to consent Exclusion Criteria: * Status 1a * Cardiac or pulmonary disease * Prior liver transplant * Requiring pressors at the time of liver offer * MELD\<15 and asymptomatic from liver disease
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06088758 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Liver Transplant. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06088758 currently recruiting?
Yes, NCT06088758 is actively recruiting participants. Contact the research team at hyeh@mgh.harvard.edu for enrollment information.
Where is the NCT06088758 trial being conducted?
This trial is being conducted at Boston, United States.
Who is sponsoring the NCT06088758 clinical trial?
NCT06088758 is sponsored by Massachusetts General Hospital. The trial plans to enroll 200 participants.