| NCT ID | NCT05460468 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Duke University |
| Condition | Mild Cognitive Impairment |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2024-03-28 |
| Primary Completion | 2027-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 150 participants in total. It began in 2024-03-28 with a primary completion date of 2027-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study network activation and neural oscillatory mechanisms underlying the network that regulates working memory and then target this network using closed-loop TMS to the Prefrontal Cortex. Investigators will measure the impact of TMS on working memory performance and task-based neural activity. The project will use brain stimulation and network modeling techniques to enhance working memory in healthy older adults and MCI and will demonstrate the value of closed-loop, network-guided TMS for future clinical applications.
Eligibility Criteria
Inclusion Criteria: * English Speaking * Willing to provide consent Exclusion Criteria: * History of any Axis I DSM-V disorder, excluding major depressive disorder or generalized anxiety disorders * Current history of substance abuse or dependence (excluding nicotine) * Intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus Nerve stimulation device * Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 5 minutes. * Neurological disorder including, but not limited to: space occupying brain lesion; any history of seizures, history of cerebrovascular accident; fainting, cerebral aneurysm, Dementia, Hungtington chorea; Multiple Sclerosis. * Current use of medications known to lower the seizure threshold and/or affect working memory
Contact & Investigator
Simon W Davis, PhD
PRINCIPAL INVESTIGATOR
Duke University
Frequently Asked Questions
Who can join the NCT05460468 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Mild Cognitive Impairment. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05460468 currently recruiting?
Yes, NCT05460468 is actively recruiting participants. Contact the research team at simon.davis@duke.edu for enrollment information.
Where is the NCT05460468 trial being conducted?
This trial is being conducted at Durham, United States.
Who is sponsoring the NCT05460468 clinical trial?
NCT05460468 is sponsored by Duke University. The principal investigator is Simon W Davis, PhD at Duke University. The trial plans to enroll 150 participants.