NCT06040073 Natural History of Coronary Atherosclerosis
| NCT ID | NCT06040073 |
| Status | Recruiting |
| Phase | — |
| Sponsor | China National Center for Cardiovascular Diseases |
| Condition | Coronary Artery Disease Progression |
| Study Type | OBSERVATIONAL |
| Enrollment | 125 participants |
| Start Date | 2024-07-07 |
| Primary Completion | 2025-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 125 participants in total. It began in 2024-07-07 with a primary completion date of 2025-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The present study sought to explore the predictive value of radial wall strain (RWS, derived solely from angiograms) for coronary artery lesion progression compared with lesion vulnerability assessed by optical coherence tomography (OCT). The lesion progression at 1 year was defined as an increase of ≥20% in diameter stenosis based on quantitative coronary angiography (QCA) evaluation.
Eligibility Criteria
Inclusion Criteria: * General Inclusion Criteria: 1. Age ≥18 years 2. Acute myocardial infarction ≤ 45 days 3. Planned coronary angiography examination or potential interventional treatment * Angiographic Inclusion Criteria: 1. The presence of at least 1 non-flow-restricting lesion (visually estimated diameter stenosis: 30%-80%; QFR \> 0.80) in any non-infarct related artery with RVD ≥2.5 mm by visual assessment Exclusion Criteria: * General exclusion Criteria: 1. Cardiogenic shock 2. Pregnant or woman of child-bearing potential 3. Life expectancy less than 1 year for non-cardiac causes 4. Unable to tolerate contrast agents or anticoagulant/antiplatelet therapy 5. Prior CABG or planned CABG * Angiographic exclusion Criteria: 1. Poor angiographic image quality precluding vessel contour detection or with suboptimal contrast opacification, branch ostium cannot be shown clearly, severe overlap in the stenosed segment or severe tortuosity of any interrogated vessel deemed not amenable to QFR or RWS measurement 2. An interrogated lesion require surgical bypass grafting 3. Unable to judge culprit lesion or infarct-related artery according to current evidence
Contact & Investigator
Lei Song, MD
PRINCIPAL INVESTIGATOR
Chinese Academy of Medical Sciences, Fuwai Hospital
Frequently Asked Questions
Who can join the NCT06040073 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Coronary Artery Disease Progression. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06040073 currently recruiting?
Yes, NCT06040073 is actively recruiting participants. Contact the research team at drsong@vip.163.com for enrollment information.
Where is the NCT06040073 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT06040073 clinical trial?
NCT06040073 is sponsored by China National Center for Cardiovascular Diseases. The principal investigator is Lei Song, MD at Chinese Academy of Medical Sciences, Fuwai Hospital. The trial plans to enroll 125 participants.