Multimodal Prehabilitation During Chemotherapy in Patients With Colorectal Liver Metastases
Trial Parameters
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Brief Summary
Liver resection is the only curative treatment for patients with colorectal liver metastases (CRLM). Most patients undergo chemotherapy (CT) before liver surgery. CT objectively decreases patient functional capacity. It has already been demonstrated that a structured training program carried out during the 4 weeks following CT, while the patient is waiting for liver resection, is able to return the functional capacity to baseline levels. Despite this, multimodal prehabilitation programs (MPP) during preoperative CT have not been evaluated or implemented. The aim of this study is to investigate whether a 16-week MPP applied during and following CT in CRLM patients will result in a significant increase in physical fitness when compared to those that undergo MPP only during the 4-weeks, between the end of CT and liver resection.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years * Written informed consent obtained from subject to participate in the study. Exclusion Criteria: * Age \<18 years * ASA health class status IV-V * Mental conditions or disabling orthopedic and neuromuscular disease that prevent physical exercise or may compromise adherence to the program * Medical contraindication to perform exercise * Inability to obtain informed consent