Whole Course Multi-model Prehabilitation to Improve Clinical Outcome in Patients Undergoing Neoadjuvant Treatment Prior to Gastrectomy
Trial Parameters
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Brief Summary
The intention of research is to establish a multimodal prehabilitation protocol in patients who undergo neoadjuvant chemotherapy prior to gastrectomy, explore the feasibility and effectiveness of the measures and evaluate the effect of program on short-term clinical outcome, fitness and long-term prognosis.
Eligibility Criteria
Inclusion Criteria: 1. Aged ≥18 years; 2. Eastern Cooperative Oncology Group (ECOG) performance status score ≤2； 3. Endoscopic biopsies were pathologically confirmed as gastric adenocarcinoma； 4. The feasibility of neoadjuvant therapy was suggested by MDT, and the feasibility of radical gastrectomy was re-evaluated after neoadjuvant therapy; 5. Blood routine, liver function, kidney function, heart function and lung function were normal before neoadjuvant therapy, and there was no contraindication of chemotherapy and surgery; 6. The pregnancy test was negative within 1 month, and she was not pregnant or breastfeeding; 7. Informed consent and ability to comply with research protocols. Exclusion Criteria: 1. metastasis; 2. End-stage cardiac insufficiency (LVEF\<30% or NYHA class IV), liver cirrhosis (Child-Pugh classification C), End-stage renal failure (receives chronic dialysis), or ASA grade IV; 3. Cerebral hemorrhage, cerebral infarction, TIA or central nervous system disease or menta