NCT04806568 MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients with Multiple Sclerosis
| NCT ID | NCT04806568 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Aristotle University Of Thessaloniki |
| Condition | Multiple Sclerosis |
| Study Type | INTERVENTIONAL |
| Enrollment | 180 participants |
| Start Date | 2020-12-01 |
| Primary Completion | 2025-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 180 participants in total. It began in 2020-12-01 with a primary completion date of 2025-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program
Eligibility Criteria
Inclusion Criteria for people with MS: * Male/female patients aged 18 to 65 years at screening * Diagnosis of MS according to the 2017 Revised McDonald criteria * Disability status at screening with an EDSS score of 0 to 6.5 * Relapsing MS and progressive MS as defined by Lublin * Neurologically stable within 1 month prior to screening * Patients receiving the same Disease Modifying Treatment (DMT) for at least 6 months Exclusion Criteria for people with MS: * Patients suspected of not being able or willing to cooperate or comply with study protocol requirements * Patients meeting criteria for other demyelinating diseases of the CNS * Patients with active chronic disease (or stable but treated with immune therapy) of the immune system other than MS * Patients with any other significant CNS disease or serious psychiatric disorder which can interfere with the patient's ability to cooperate or comply with the study procedure * Patients unable or unwilling to undergo MRI scans and EEG Inclusion Criteria for Healthy Controls: • Normal hearing and normal or corrected-to-normal vision Exclusion Criteria for Healthy Controls: * Any diagnosed neurological, mental, developmental, or psychiatric disorder * Unrecovered neurological disorders (i.e., stroke, traumatic brain injury) * Unstable medication within the last 3 months * Intake of central nervous drugs (e.g., antidepressants) * Severe physical disorder * Concurrent participation in another relevant study * Patients unable or unwilling to undergo EEG measurements
Contact & Investigator
Charis Styliadis, PhD
PRINCIPAL INVESTIGATOR
Aristotle University Of Thessaloniki
Frequently Asked Questions
Who can join the NCT04806568 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Multiple Sclerosis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04806568 currently recruiting?
Yes, NCT04806568 is actively recruiting participants. Contact the research team at styliadis@hotmail.com for enrollment information.
Where is the NCT04806568 trial being conducted?
This trial is being conducted at Thessaloniki, Greece.
Who is sponsoring the NCT04806568 clinical trial?
NCT04806568 is sponsored by Aristotle University Of Thessaloniki. The principal investigator is Charis Styliadis, PhD at Aristotle University Of Thessaloniki. The trial plans to enroll 180 participants.
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