Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis
This study examines how immune cells called monocytes behave in critically ill patients with a serious blood infection caused by Pseudomonas aeruginosa bacteria. Researchers want to understand whether these immune cells are more inflammatory or anti-inflammatory, and how this relates to the severity of the infection.
Key Objective: This research could help doctors better understand and potentially improve treatment strategies for severe Pseudomonas aeruginosa infections by identifying key immune cell patterns.
Who to Consider: Critically ill patients hospitalized with confirmed or suspected Pseudomonas aeruginosa sepsis may be candidates for this observational study.
Trial Parameters
Brief Summary
The present study focuses on patients with Pseudomonas aeruginosa (PSA) sepsis. The aim of the present study is to find out whether the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype predominates in blood monocytes in critically ill patients with PSA-sepsis, and whether the severity of sepsis and outcome is associated with distinct monocyte phenotype and function.
Eligibility Criteria
Inclusion Criteria: * age \> 18 years * critically ill patients with sepsis * microbiologically proven infection with Pseudomonas aeruginosa Exclusion Criteria: * life expectancy \< 24 hours * participation in other studies