NCT04185935 Molecular Genetics Studies of Cancer Patients and Their Relatives
| NCT ID | NCT04185935 |
| Status | Recruiting |
| Phase | — |
| Sponsor | City of Hope Medical Center |
| Condition | Malignant Neoplasm |
| Study Type | OBSERVATIONAL |
| Enrollment | 999,999 participants |
| Start Date | 1997-04-18 |
| Primary Completion | 2033-08-18 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 999,999 participants in total. It began in 1997-04-18 with a primary completion date of 2033-08-18.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.
Eligibility Criteria
Inclusion Criteria: * Individuals must have a personal history of cancer and/or a family history of cancer suggestive of the presence of an inherited predisposition. This inherited predisposition might manifest as: * Young age cancer diagnosis * Multiple primary neoplasms in affected member * The presence of rare tumor types in the family * Congenital malformations * Any other family clustering of cancer * Any other cancer-predisposing genetic diseases/conditions * Individuals may also be eligible by participation in the City of Hope Cancer Screening \& Prevention Program Network (CSPPN) clinical service or on the basis of membership in a group known or suspected to have an increased risk of carrying a genetic alteration or of sustaining a particular exposure that would place that at increased risk of cancer. (Examples would include members of occupational cohorts like asbestos workers, individuals with multiple dysplastic nevi in the absence of a family history of cancer, and individuals descended from a particular tribe in the American Southwest who have an increased incidence of a rare genetic alteration associated with an increased risk of a specific cancer.) * Individuals and families may be referred to us in a number of different ways. After initial contact is made with a individual or family by family studies personnel; an individual within the bloodline will be identified as the historian. There may be more than one historian within a family * At least one historian must be wiling to provide information or access as needed to contact appropriate family members for documentation of cancer and for consent. An individual is considered to be eligible to participate if they criteria; contact with relatives is not always indicated * Individuals who are under 18 are eligible for study if they meet the criteria. Consent for participation must be given by a legal guardian or parent * Deceased patients may be included in the study. Public records, such as death certificates, can be used to confirm information from individuals or family members. If medical records are needed, consent for these records will be obtained from the deceased's next of kin. Next of kin refers to the following hierarchy of relatives; spouse, offspring, parents, and siblings. (Any further use of next of kin in this protocol should relate back to this hierarchy.) Archived tissue samples, such as pathology blocks or snap frozen tumor from a pathology department tumor bank (discard specimens) may be used for genetic research Exclusion Criteria: * A family may be ineligible for study if the historian will not allow access to anyone within the family and thus, the accuracy of the family history cannot be established
Contact & Investigator
Stephen Gruber
✉ sgruber@coh.orgStephen Gruber, MD
PRINCIPAL INVESTIGATOR
City of Hope Medical Center
Frequently Asked Questions
Who can join the NCT04185935 clinical trial?
This trial is open to participants of all sexes, studying Malignant Neoplasm. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04185935 currently recruiting?
Yes, NCT04185935 is actively recruiting participants. Contact the research team at sgruber@coh.org for enrollment information.
Where is the NCT04185935 trial being conducted?
This trial is being conducted at Phoenix, United States, Concord, United States, Duarte, United States, Fullerton, United States and 11 additional locations.
Who is sponsoring the NCT04185935 clinical trial?
NCT04185935 is sponsored by City of Hope Medical Center. The principal investigator is Stephen Gruber, MD at City of Hope Medical Center. The trial plans to enroll 999,999 participants.