Trial Parameters
Brief Summary
Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescents Aim 2a. To determine hormonal, psychophysical, and neural changes associated with migraine onset. Aim 2b. To identify the temporal relationships between hormonal, psychophysical, and neural changes preceding vs. following migraine onset. Aim 3. To identify psychophysical and neural factors predicting migraine prognosis in adolescents with migraine.
Eligibility Criteria
Inclusion criteria for healthy participants: 1. Age 10-13 2. Males or females (biological sex) 3. Not diagnosed with migraine or having migraine symptoms 4. With a first degree relative diagnosed with migraine (for the Fam-His group) or without a first or a second degree relative diagnosed with migraine (for the No-Fam-His group) Inclusion criteria for participants with migraine: 1. Age 10-13 2. Males or females (biological sex) 3. Diagnosed with migraine or having migraine symptoms 4. Migraine duration \> 6 months 5. Without preventative treatment or with stable preventative treatment for migraine (no change in intervention in the last 6 months) Exclusion Criteria for the healthy group: * Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion: 1. Diagnosis of any chronic pain syndrome 2. Diagnosis of a neurological, developmental, pubertal, or psychiatric disorder 3. Taking pain or psychiatric medications regularly 4. Having a