Medical Condition

migraine

Q: How many clinical trials are currently recruiting for migraine?

ClinicalMetric currently tracks 16 actively recruiting clinical trials for migraine, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 16. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

Q: What trial phases are available for migraine?

migraine research spans Phase 3 (2 trials), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

Q: How do I find out if I qualify for a migraine clinical trial?

Eligibility criteria for migraine trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Total Trials

16

Recruiting Now

16

Trial Phases

Phase 3, Phase 4

Migraine is a debilitating neurological condition affecting approximately 1 billion people globally, ranking as the second leading cause of disability worldwide by years lived with disability. Clinical trials have transformed acute and preventive treatment, with the CGRP pathway now the most actively targeted mechanism β€” producing anti-CGRP monoclonal antibodies (erenumab, fremanezumab, galcanezumab, eptinezumab) and oral CGRP receptor antagonists (rimegepant, ubrogepant, atogepant) as approved agents, with numerous successors in trials.

Current trials investigate next-generation anti-CGRP agents with extended dosing intervals, combination preventive strategies for high-frequency migraine, valrocemide and Nav1.7 inhibitors for treatment-resistant patients, and non-pharmacological approaches including non-invasive vagus nerve stimulation (nVNS), TMS devices, and digital therapeutics. Trials also address cluster headache, chronic migraine, and vestibular migraine as distinct entities.

Migraine frequency (episodic: <15 headache days/month; chronic: β‰¥15/month) and medication overuse history are key eligibility criteria; biomarker-based enrichment trials use CGRP blood levels.

Frequently Asked Questions — migraine Clinical Trials

How many clinical trials are currently recruiting for migraine?

ClinicalMetric currently tracks 16 actively recruiting clinical trials for migraine, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 16. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for migraine?

migraine research spans Phase 3 (2 trials), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a migraine clinical trial?

Eligibility criteria for migraine trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 3

Phase 4

Top Sponsors

Fondazione Policlinico Universitario Agostino Gemelli IRCCS 1 trial

AbbVie 1 trial

Medstar Health Research Institute 1 trial

University of Aarhus 1 trial

Medical University Innsbruck 1 trial

migraine

Frequently Asked Questions — migraine Clinical Trials

Recruiting Clinical Trials

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