NCT07414498 MICRO-SURG: Subgingival Microbiome in Peri-Implantitis, Regenerative, and Resective Periodontal Surgery
| NCT ID | NCT07414498 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital Muenster |
| Condition | Periodontitis |
| Study Type | INTERVENTIONAL |
| Enrollment | 84 participants |
| Start Date | 2026-02-23 |
| Primary Completion | 2026-05-18 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 84 participants in total. It began in 2026-02-23 with a primary completion date of 2026-05-18.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This clinical study investigates how the subgingival microbiome changes after three different periodontal and peri-implant surgical procedures: (1) resective periodontal surgery, (2) regenerative periodontal surgery, and (3) peri-implantitis surgery. The aim is to characterize microbial shifts associated with these commonly used surgical treatments and to determine whether the type of surgery influences the recovery or disruption of the subgingival ecosystem. Adult patients with periodontitis or peri-implantitis will receive the procedure indicated for their condition. Subgingival plaque samples will be collected at baseline and at defined postoperative follow-up intervals. Microbiome analysis will be performed using next-generation sequencing (NGS), and microbial changes will be evaluated with the Subgingival Microbial Dysbiosis Index (SMDI). Insights from this study may help improve prevention, diagnostics, and treatment strategies for periodontal and peri-implant diseases.
Eligibility Criteria
Inclusion Criteria: * Age 18 years or older * Confirmed diagnosis of Peri-implantitis (for the peri-implantitis surgery arm), or Stage III/IV periodontitis (for the periodontal surgery arms) * Indication for surgical therapy corresponding to the assigned study arm * Ability to understand the study procedures and provide written informed consent * Adequate oral hygiene (API/SBI according to the clinician's judgment) * Willingness and ability to attend all follow-up visits * Willingness to provide salivary and subgingival plaque samples for microbiome analyses (NGS, SMDI) Exclusion Criteria: * Systemic conditions contraindicating oral surgical procedures * Severe systemic diseases (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders) * Use of systemic antibiotics within the previous 3 months * Active COVID-19 infection at the time of surgery * Pregnancy or breastfeeding * Drug or alcohol abuse * Smoking more than 10 cigarettes per day * Known allergies to materials used in the assigned intervention (e.g., local anesthetics, sutures, membranes, bone grafting materials) * Participation in another clinical study within the previous 30 days * Acute oral infections that contraindicate participation * Inability or unwillingness to comply with all follow-up appointments Lack of capacity to provide informed consent
Contact & Investigator
Benjamin Ehmke, Univ. Prof. Dr. med. dent.
PRINCIPAL INVESTIGATOR
Clinic for Periodontology and Conservative Dentistry, University of Münster
Frequently Asked Questions
Who can join the NCT07414498 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Periodontitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07414498 currently recruiting?
Yes, NCT07414498 is actively recruiting participants. Contact the research team at ehmke@uni-muenster.de for enrollment information.
Where is the NCT07414498 trial being conducted?
This trial is being conducted at Münster, Germany.
Who is sponsoring the NCT07414498 clinical trial?
NCT07414498 is sponsored by University Hospital Muenster. The principal investigator is Benjamin Ehmke, Univ. Prof. Dr. med. dent. at Clinic for Periodontology and Conservative Dentistry, University of Münster. The trial plans to enroll 84 participants.