← Back to Clinical Trials
Recruiting NCT04430075

NCT04430075 MiCLASP Post Market Clinical Follow-Up (PMCF) Study

◆ AI Clinical Summary
Plain-language summary for patients
Clinical Trial Summary
NCT ID NCT04430075
Status Recruiting
Phase
Sponsor Edwards Lifesciences
Condition Mitral Regurgitation
Study Type OBSERVATIONAL
Enrollment 1,000 participants
Start Date 2019-08-23
Primary Completion 2025-12-31

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age N/A
Study Type OBSERVATIONAL
Interventions
Edwards PASCAL Transcatheter Valve Repair System and Edwards PASCAL Precision Transcatheter Valve Repair System

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 1,000 participants in total. It began in 2019-08-23 with a primary completion date of 2025-12-31.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

This is a postmarket clinical follow up study on the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System and the Edwards PASCAL Precision Transcatheter Valve Repair System in transcatheter mitral valve repair.

Eligibility Criteria

Inclusion Criteria: 1. Mitral TEER patients eligible per the current approved indication after Heart Team discussion and agreement 2. Patient is willing and able to attend all follow-up visits and to perform all tests 3. Provision of written informed consent Exclusion Criteria: 1. Patients are not eligible per the current Instructions for Use 2. Non-elective or emergency TEER procedure for mitral regurgitation 3. Patients in ICU prior to the index procedure

Contact & Investigator

Central Contact

TMTT Clinical Affairs

✉ TMTT_Clinical@edwards.com

📞 +1 (949) 250

Principal Investigator

Philipp Lurz, Prof.Dr.med.

PRINCIPAL INVESTIGATOR

Johannes Gutenberg University Mainz

Frequently Asked Questions

Who can join the NCT04430075 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, studying Mitral Regurgitation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT04430075 currently recruiting?

Yes, NCT04430075 is actively recruiting participants. Contact the research team at TMTT_Clinical@edwards.com for enrollment information.

Where is the NCT04430075 trial being conducted?

This trial is being conducted at Vienna, Austria, Bad Krozingen, Germany, Tübingen, Germany, Ulm, Germany and 11 additional locations.

Who is sponsoring the NCT04430075 clinical trial?

NCT04430075 is sponsored by Edwards Lifesciences. The principal investigator is Philipp Lurz, Prof.Dr.med. at Johannes Gutenberg University Mainz. The trial plans to enroll 1,000 participants.

Related Trials

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology