NCT06929871 Mako Cementless TKA vs Mako Cemented TKA
| NCT ID | NCT06929871 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University College, London |
| Condition | Total Knee Replacement |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2025-09-29 |
| Primary Completion | 2031-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2025-09-29 with a primary completion date of 2031-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The overall aims of this prospective, randomised, single-blinded controlled trial are to compare functional, radiological and clinical outcomes in Mako robotic-arm assisted cementless Total Knee Arthroplasty (TKA) versus Mako robotic-arm assisted cemented TKA.
Eligibility Criteria
Inclusion Criteria: 1. Patient has symptomatic knee osteoarthritis requiring primary TKA 2. Patient and surgeon are in agreement that TKA is the most appropriate treatment 3. Patient is fit for surgical intervention following review by surgeon and anaesthetist 4. Patient is over 18 years old at time of surgery 5. Gender: male and female 6. Patient must be capable of giving informed consent and agree to comply with the postoperative review program 7. Patient must have sufficient postoperative mobility to attend follow-up clinics and allow for radiographs to be taken Exclusion Criteria: 1. Patient is not suitable for routine primary TKA e.g. patient has ligament deficiency that requires a constrained prosthesis 2. Patient has bone loss that requires augmentation 3. Patient is not medically fit for surgical intervention 4. Patient requires revision surgery following previously failed correctional osteotomy or ipsilateral TKA 5. Patient has a DEXA scan with T-score \< -2.5 at any point 6. Patient is immobile or has another neurological condition affecting musculoskeletal function 7. Patient is less than 18 years at time of surgery 8. Patient is unable or unwilling to sign the informed consent form specific to this study 9. Patient is unable to attend the follow-up programme 10. Previous pathological fracture
Contact & Investigator
Fares S Haddad, MBBS MD (Res) MCh (Orth) FRCS
STUDY CHAIR
UCL Hospitals NHS Foundation Trust
Frequently Asked Questions
Who can join the NCT06929871 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Total Knee Replacement. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06929871 currently recruiting?
Yes, NCT06929871 is actively recruiting participants. Contact the research team at jenni.tahmassebi1@nhs.net for enrollment information.
Where is the NCT06929871 trial being conducted?
This trial is being conducted at London, United Kingdom.
Who is sponsoring the NCT06929871 clinical trial?
NCT06929871 is sponsored by University College, London. The principal investigator is Fares S Haddad, MBBS MD (Res) MCh (Orth) FRCS at UCL Hospitals NHS Foundation Trust. The trial plans to enroll 120 participants.