NCT07791407 Magnetic Resonance Imaging Based Risk Stratification for Defibrillator Implantation in Heart Failure Patients Requiring Cardiac Resynchronisation Therapy
| NCT ID | NCT07791407 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Velammal Medical College Hospital and Research Institute |
| Condition | Non Ischemic Cardiomyopathy |
| Study Type | INTERVENTIONAL |
| Enrollment | 114 participants |
| Start Date | 2026-08-01 |
| Primary Completion | 2027-07-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 114 participants in total. It began in 2026-08-01 with a primary completion date of 2027-07-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized study aimed to compare the efficacy of LBBP without defibrillator vs biventricular pacing with defibrillator (BiV-ICD/CRT-D) in patients with LB-NICM and left ventricular ejection fraction (LVEF) ≤35% risk categorized by CMR imaging.
Eligibility Criteria
Inclusion Criteria: 1. Patients with age ≥18 years 2. Typical left bundle branch block as defined by Strauss criteria with LVEF ≤35% 3. Heart failure symptoms despite guideline directed medical therapy (GDMT) Exclusion Criteria: 1. Patients with angiographic evidence of significant coronary artery disease requiring revascularisation. In patients with significant CAD, LVEF will be re-assessed 3 months after revascularisation to decide about CRT 2. Patients with associated uncorrected congenital or valvular heart disease 3. Expected life-expectance of \<12 months due to associated comorbidities 4. Patients with contrast allergy 5. Baseline non-LBBB morphology 6. Renal dysfunction which limits the acquisition of CMR with contrast 7. Pregnant or lactating women 8. Patients who are unable to comply with study protocol
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07791407 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Non Ischemic Cardiomyopathy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07791407 currently recruiting?
Yes, NCT07791407 is actively recruiting participants. Contact the research team at shunmuga.pgi@gmail.com for enrollment information.
Where is the NCT07791407 trial being conducted?
This trial is being conducted at Madurai, India.
Who is sponsoring the NCT07791407 clinical trial?
NCT07791407 is sponsored by Velammal Medical College Hospital and Research Institute. The trial plans to enroll 114 participants.