| NCT ID | NCT05654272 |
| Status | Recruiting |
| Phase | — |
| Sponsor | The Cleveland Clinic |
| Condition | Cardiovascular Diseases |
| Study Type | OBSERVATIONAL |
| Enrollment | 1,000 participants |
| Start Date | 2022-09-09 |
| Primary Completion | 2032-09-09 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 1,000 participants in total. It began in 2022-09-09 with a primary completion date of 2032-09-09.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, there is a lack of agreement of on which markers are the most sensitive. This multi-study will allow us the unique opportunity to form a more comprehensive understanding for various cardiovascular diseases. Our team has developed novel cardiac MRI techniques that leverages endogenous tissue properties to reveal a milieu of deep tissue phenotypes including myocardial inflammation, fibrosis, metabolism, and microstructural defects. Among these phenotypes, myocardial microstructure has proven to be most sensitive to early myocardial tissue damage and is predictive of myocardial regeneration. In this study, the investigators aim to further study the importance of cardiac microstructure revealed by MRI in patient and healthy population and compare this novel technology with conventional clinical biomarkers.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years of age * Provision of written informed consent * If not healthy volunteer, must be diagnosed with cardiovascular disease Exclusion Criteria: * Vulnerable populations will be excluded from this study including Prisoners * Other contraindications to CMR imaging to be determined by standard MRI protocols * Decisionally impaired (e.g., dementia or cognitive disability)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05654272 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Cardiovascular Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05654272 currently recruiting?
Yes, NCT05654272 is actively recruiting participants. Contact the research team at circ@ccf.org for enrollment information.
Where is the NCT05654272 trial being conducted?
This trial is being conducted at Cleveland, United States.
Who is sponsoring the NCT05654272 clinical trial?
NCT05654272 is sponsored by The Cleveland Clinic. The trial plans to enroll 1,000 participants.