| NCT ID | NCT06073834 |
| Status | Recruiting |
| Phase | — |
| Sponsor | BioMérieux |
| Condition | VAP - Ventilator Associated Pneumonia |
| Study Type | OBSERVATIONAL |
| Enrollment | 68 participants |
| Start Date | 2023-12-05 |
| Primary Completion | 2026-04 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
objective of LUNG-I3 study is to assess the quantitative and functional differences in cells between blood and bronchoalveolar lavage (BAL) fluid after an infection, with a special focus on alveolar macrophages and neutrophils
Eligibility Criteria
Inclusion Criteria: All the following criteria * Age 18 years or greater * Severe ICU patients hospitalized for one of the above diseases: * Septic shock (requirement of vasopressor to maintain a mean arterial pressure of 65 mm Hg or greater and serum lactate level greater than 2 mmol/L (\>18 mg/dL) in the absence of hypovolemia) caused either by pneumonia (n=20) or another source n=20) * Severe trauma (level I and II), Injury Severity Score ≥ 25 OR * Burn with TBSA over 20% * NAD \> 0.1 µg/kg/min * At least 2 SOFA criteria ≥ 2 points Exclusion Criteria: * Aspiration pneumonia * Unable to obtain a valid and written consent from a patient or their legally authorized representative in accordance with the local regulatory instances (this includes in FR: Person not affiliated to a health insurance scheme, or not a beneficiary of such a scheme. Persons who are the subject of a legal protection order. Person with restricted freedom following a legal or administrative decision and a person ad