Efficiency and Safety of the Prolonged Use of Heat and Moisture Exchangers in ICU
Trial Parameters
Brief Summary
FILTRex is a single-centre, controlled, randomised, prospective, non-inferiority clinical trial to compare the efficiency and safety of prolonged (72-hours) versus standard (24-hours) duration of use for Heat and Moisture Exchange (HME) filters in adult mechanically ventilated critically ill patients
Eligibility Criteria
Inclusion Criteria: 1. Age ≥18 years 2. In-patient in ICU and expected to stay \> 3 days 3. Mechanical ventilation or imminent need of it; predicted length of mechanical ventilation ≥ 72h 4. Clinical Pulmonary Infection score (CPIS) less than six at the baseline 5 No history and symptoms of aspiration at the baseline Exclusion Criteria: 1. Suspected pulmonary infection on admission and in the first 48 hours of mechanical ventilation 2. Pregnancy 3. Acute respiratory distress syndrome 4. Body temperature \< 32°C 5. Airway bleeding or other contraindications for the use of HME 6. An early decision of treatment withdrawal