Trial Parameters
Brief Summary
This study will examine the pain-relief efficacy and safety of L-arginine in knee OA patients.
Eligibility Criteria
Inclusion Criteria: 1. Age between 40 and 80 years. 2. Knee OA according to the American College of Rheumatology (ACR) clinical criteria. 3. Knee pain lasting 3 months or longer and a score of 7 or greater on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale (standardized to range from 0-20). 4. Kellgren-Lawrence (KL) grade 2 or 3. 5. Willing to and able to provide written informed consent. Exclusion Criteria: 1. Any use of NSAIDs or other analgesics in the past two weeks. 2. History of injections of corticosteroids in the past three months or hyaluronic acid in the past 6 months in the index knee. 3. History of arthroscopy or open surgery in the index knee in the past 12 months. 4. History of a knee replacement in the index knee or planning to receive such a procedure within 3 months. 5. History of a severe injury in the index knee. 6. Pain in the index knee caused by inflammatory, autoimmune, neoplastic diseases or other diseases. 7. Abnormal li