NCT06208631 Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis
| NCT ID | NCT06208631 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Stanford University |
| Condition | Osteoarthritis, Knee |
| Study Type | INTERVENTIONAL |
| Enrollment | 31 participants |
| Start Date | 2024-01-18 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 31 participants in total. It began in 2024-01-18 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading. Prior research has utilized musculoskeletal simulations to determine that reducing the activation of one of the calf muscles, the gastrocnemius, can have a large impact on reducing knee loading. However, this has not been tested in individuals with knee osteoarthritis. In this study, participants will be trained to alter the activation of their gastrocnemius muscle, by receiving haptic feedback after each step. The feedback will indicate how the participant changed their muscle activation relative to baseline. Some participants will train on a treadmill in the laboratory for up to two sessions, with 30 minutes of walking with feedback in each session. If a participant can learn to adjust their muscle activation in the first training session, they will be able to complete the second training session. Other participants will train outside the laboratory for one session with 30 minutes of walking with feedback to investigate changes in knee loading while using the new walking strategy during over-ground walking. The movement data collected during the training sessions will be used as inputs to computer simulations of the musculoskeletal system to determine if walking with the new muscle activation strategy reduces knee loading.
Eligibility Criteria
Inclusion Criteria: * Medial and/or lateral compartment knee osteoarthritis * Diagnosed with knee osteoarthritis of at least six months duration * Ambulatory without aids * Able to walk for at least 60 minutes * Typical pain rating less than or equal to 4 on scale of 0-10 * Able to reduce gastrocnemius muscle activation by 10% from baseline Exclusion Criteria: * History of symptomatic arthritis in lower limb joints other than the knees * Replacement of any lower extremity joint * Symptoms originating from the patellofemoral joint * Body mass index equal to or greater than 35 * Nerve or muscle disease associated with walking difficulty * History of rheumatoid arthritis, gout, or autoimmune disease * History of lower limb fracture or surgery requiring hospitalization * Pregnant
Contact & Investigator
Scott L Delp, PhD
PRINCIPAL INVESTIGATOR
Stanford University
Frequently Asked Questions
Who can join the NCT06208631 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Osteoarthritis, Knee. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06208631 currently recruiting?
Yes, NCT06208631 is actively recruiting participants. Contact the research team at oawalking@lists.stanford.edu for enrollment information.
Where is the NCT06208631 trial being conducted?
This trial is being conducted at Stanford, United States.
Who is sponsoring the NCT06208631 clinical trial?
NCT06208631 is sponsored by Stanford University. The principal investigator is Scott L Delp, PhD at Stanford University. The trial plans to enroll 31 participants.