Trial Parameters
Condition Soft Tissue Sarcoma
Sponsor University Health Network, Toronto
Study Type INTERVENTIONAL
Phase Phase 2
Enrollment 145
Sex ALL
Min Age 18 Years
Max Age 100 Years
Start Date 2024-03-05
Completion 2027-11-30
Interventions
RadiotherapySurgery
Brief Summary
The hypoxia \> metastasis axis suggests that a DWI-based biomarker of hypoxia incorporating IVIM may be able to predict metastasis in STS patients, ultimately enabling stratification for personalized treatments at the time of diagnostic (MR) imaging, without adding an excessive burden to the patient or clinical workflow (typical DWI/IVIM sequences can be acquired acquired in approximately 5 minutes).
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years * Ability to understand and the willingness to sign a written informed consent document * Grade 2 or 3 soft tissue sarcoma greater than 5 cm in largest dimension Exclusion Criteria: * Contraindication to MRI scan as per current institutional guidelines (for patients requiring MRI)