NCT07510269 Investigation of the Effects of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block on Perioperative Analgesia Management in Patients Scheduled for Mastectomy

Eligibility & Interventions

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This trial targets 66 participants in total. It began in 2025-10-15 with a primary completion date of 2026-09-15.

Brief Summary

This study aims to evaluate and compare the analgesic efficacy of two ultrasound-guided regional anesthesia techniques, the serratus anterior plane (SAP) block and the serratus posterior superior intercostal plane (SPSIP) block, in patients undergoing elective mastectomy surgery. Postoperative pain following mastectomy is a common and significant clinical problem that negatively affects patient comfort, delays mobilization, and may prolong hospital stay. Although systemic analgesics are commonly used, they are associated with adverse effects such as sedation, constipation, and potential dependency. In this randomized clinical study, female patients aged 18-75 years with ASA physical status I-III scheduled for elective mastectomy will be included after obtaining informed consent. Patients will be allocated into two groups to receive either SAP block or SPSIP block under ultrasound guidance prior to surgery. Standardized general anesthesia and perioperative analgesia protocols will be applied to all patients. The primary objective is to compare postoperative pain scores between the two groups using the Numeric Rating Scale (NRS). Secondary outcomes include time to first analgesic requirement, total analgesic consumption, intraoperative opioid use, and hemodynamic parameters. By comparing these two interfascial plane blocks, this study aims to identify a more effective analgesic technique that improves postoperative pain control, enhances patient comfort, and facilitates early mobilization following mastectomy.

Eligibility Criteria

Inclusion Criteria: * Female patients aged between 18 and 75 years * Patients scheduled for elective mastectomy surgery * American Society of Anesthesiologists (ASA) physical status I-III * Patients who provide written informed consent Exclusion Criteria: * Patients who refuse to participate in the study * Patients with American Society of Anesthesiologists (ASA) physical status IV or V * Patients receiving anticoagulant therapy or with suspected coagulopathy * Patients with known allergy to local anesthetic agents * Infection at the site of block application * Pregnant patients or those with suspected pregnancy * Patients with severe neurological or psychiatric disorders * Patients with severe cardiovascular disease * Patients with chronic opioid use * Patients with hepatic failure or renal failure (glomerular filtration rate \<15 mL/min/1.73 m²)

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