Intake of Nitrate-rich Vegetables and Their Effect on Inflammatory Molecules and Oral Microbiota of Patients With Periodontitis
This study examines whether eating nitrate-rich vegetables like spinach, kale, and beets can help reduce inflammation and improve the balance of bacteria in the mouths of people with gum disease. Researchers will track changes in inflammatory markers and oral bacteria in participants who increase their vegetable intake.
Key Objective: The trial is testing whether a diet rich in nitrate-containing vegetables can reduce inflammation and modify harmful oral bacteria in patients with periodontitis.
Who to Consider: Patients diagnosed with periodontitis (gum disease) who are interested in exploring dietary approaches to complement their current periodontal treatment should consider enrolling.
Trial Parameters
Brief Summary
Vegetables, mainly green leafy ones and some others like beets, are a rich source of nitrate. Nitrate metabolism has shown benefits to the body and there are recent studies that agree that the consumption of nitrates from vegetables can modify the oral microbiota by increasing species with nitrate-reducing capacity, which are also bacteria that are associated with oral health.
Eligibility Criteria
Inclusion Criteria: * Men and/or women from 30 to 65 years old * Voluntary participation and signing the written informed consent * Not receiving nutritional treatment at the time of uptake * Availability to attend all scheduled visits * Have an indication to receive nonsurgical periodontal treatment (NSPT) * Interdental clinical insertion loss ≥3mm and ≥5mm in the buccal or oral area of two or more non-adjacent teeth * Detectable depths ≥ 5mm in two or more teeth * Radiographic evidence of periodontal bone loss Exclusion Criteria: * Trauma-Induced Gingival Recessions * Cervical caries * History of bleeding diathesis * Pregnant or nursing women * BMI \<18.5 kg / m2 * History of any of the following self-reported diseases: type 2 diabetes mellitus, high blood pressure, kidney or liver disease, inflammatory bowel diseases, autoimmune diseases and/ or use of medications to control these diseases. * Having or presenting a high risk of infection by tuberculosis, hepatitis B or Human Immunod