NCT06136195 Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
| NCT ID | NCT06136195 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | Yale University |
| Condition | Alcohol Consumption |
| Study Type | INTERVENTIONAL |
| Enrollment | 63 participants |
| Start Date | 2024-07-01 |
| Primary Completion | 2026-05-31 |
Trial Parameters
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Brief Summary
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
Eligibility Criteria
Inclusion Criteria: 1. Ages 21-50 (The lower limit is to avoid offering alcohol to individuals below the drinking age of 21. The upper age is determined by experience recruiting for our prior studies). 2. Ability to read English at 6th grade level or higher. 3. Meet DSM-V criteria for moderate or severe Alcohol Use Disorder (AUD). 4. Average weekly alcohol consumption of 30-70 standard drinks for men and 20-65 drinks for women. The lower limits are consistent with the lower sex-specific cut-offs defining high-risk drinking based on World Health Organization Risk Levels (WHO, 2000); the upper limits are designed to avoid recruiting participants whose drinking is likely to exceed the number of drinks available in the Alcohol Drinking Paradigm (ADP). Exclusion Criteria: 1. Individuals who are seeking alcohol treatment or have been in alcohol treatment within the past 6 months. 2. Meet current Diagnostic and Statistical Manual v.5 (DSM-V) criteria for substance use disorder, except for tob