NCT06953375 Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty
| NCT ID | NCT06953375 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Colorado, Denver |
| Condition | Total Knee Arthroplasty |
| Study Type | INTERVENTIONAL |
| Enrollment | 3,250 participants |
| Start Date | 2025-05-12 |
| Primary Completion | 2029-04 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 3,250 participants in total. It began in 2025-05-12 with a primary completion date of 2029-04.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Patients experience dramatic quadriceps strength loss after total knee replacement, which contributes to persistent weakness and reduced long-term function after surgery. Neuromuscular electrical stimulation (NMES) reduces quadriceps weakness and improves patient function after knee replacement, but it is drastically underused in rehabilitation practice. This randomized trial will examine the effectiveness and feasibility of a comprehensive strategy for implementing neuromuscular electrical stimulation after knee replacement in two large healthcare organizations.
Eligibility Criteria
Inclusion Criteria: Site Inclusion Criteria: • UCHealth or Intermountain Health outpatient physical therapy clinic Patient Inclusion Criteria: * Underwent primary unilateral TKA * Attended outpatient rehabilitation at a participating clinic within 5 days after TKA * Attended at least 3 total outpatient physical therapy visits in total Exclusion Criteria: Patient Exclusion Criteria: * NMES Contraindications \[Patients with implanted cardiovascular cardiovertedefibrillator (ICD), active cancer, post-operative diagnosed deep vein thrombosis (DVT) in involved lower extremity\] * Previous lower extremity arthroplasty less than 12 weeks prior to scheduled TKA surgical date
Contact & Investigator
Jennifer Stevens-Lapsley, PT, PhD
PRINCIPAL INVESTIGATOR
University of Colorado, Denver
Frequently Asked Questions
Who can join the NCT06953375 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Total Knee Arthroplasty. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06953375 currently recruiting?
Yes, NCT06953375 is actively recruiting participants. Contact the research team at maggie.givan@cuanschutz.edu for enrollment information.
Where is the NCT06953375 trial being conducted?
This trial is being conducted at Aurora, United States, Aurora, United States, Murray, United States.
Who is sponsoring the NCT06953375 clinical trial?
NCT06953375 is sponsored by University of Colorado, Denver. The principal investigator is Jennifer Stevens-Lapsley, PT, PhD at University of Colorado, Denver. The trial plans to enroll 3,250 participants.