NCT06788743 Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
| NCT ID | NCT06788743 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Xijing Hospital |
| Condition | Postoperative Delirium (POD) |
| Study Type | INTERVENTIONAL |
| Enrollment | 450 participants |
| Start Date | 2025-06-01 |
| Primary Completion | 2026-04-24 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 450 participants in total. It began in 2025-06-01 with a primary completion date of 2026-04-24.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The present study is a multicenter， randomized controlled clinical trial, which plans to enroll 450 diabetic patients aged more than 60 years. The participants will be randomly assigned in a 1:1 ratio and will receive either propofol or sevoflurane for intraoperative anesthesia maintenance to evaluate the impact of these two anesthetic drugs on postoperative delirium. The aim of our study is to explore whether the use of propofol for anesthesia maintenance in elderly diabetic patients undergoing elective non-cardiac major surgery can reduce the incidence of postoperative delirium. This study will provide new perspectives for improving perioperative management in elderly diabetic patients and optimizing anesthesia management strategies to reduce the risk of postoperative delirium.
Eligibility Criteria
Inclusion Criteria: * Age ≥60 years * Elective surgery (with an expected duration of 2 hours or more) * ASA grade Ⅰ-Ⅲ * Voluntary participation and informed consent obtained * Diabetes mellitus Exclusion Criteria: * Pre-operative BMI≥35 kg/m² (Class II obesity or above) * Severe hepatic dysfunction (Child-Pugh class C) or pre-operative dialysis-dependent renal dysfunction * Known neurological or psychiatric diseases (Parkinson's disease, depression, schizophrenia), or cognitive impairment (dementia) * Severe visual or auditory impairments, language barriers, or patients who cannot cooperate * Long-term use of sedatives, antipsychotic drugs, or long-term alcohol abuse * Neurosurgical patients * Patients with a known allergy to the drugs used in this study or those suspected of having propofol infusion syndrome
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06788743 clinical trial?
This trial is open to participants of all sexes, aged 60 Years or older, studying Postoperative Delirium (POD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06788743 currently recruiting?
Yes, NCT06788743 is actively recruiting participants. Contact the research team at niehuang@163.com for enrollment information.
Where is the NCT06788743 trial being conducted?
This trial is being conducted at Xi’an, China.
Who is sponsoring the NCT06788743 clinical trial?
NCT06788743 is sponsored by Xijing Hospital. The trial plans to enroll 450 participants.