Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery
Trial Parameters
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
Brief Summary
For patients after surgery, quality of recovery has significant impacts on the prognosis, quality of life, and rational allocation of medical resources. Dexmedetomidine and esketamine have each been used during the perioperative period and improved postoperative analgesia and subjective sleep quality. This 2x2 factorial trial is designed to explore the effects of dexmedetomidine, esketamine, and their combination on the quality of recovery in patients recovering from surgery under general anesthesia.
Eligibility Criteria
Inclusion Criteria: * Aged 18 years or over; * Scheduled to undergo surgery under general anesthesia, with an expected surgical duration of at least 1 hour; * Required patient-controlled intravenous analgesia after surgery. Exclusion Criteria: * Unable to communicate preoperatively due to visual, auditory, or verbal barriers or other reasons; * Severe bradycardia (heart rate \<50 bpm), sick sinus syndrome, or grade 2 or higher atrioventricular block without pacemaker; * History of hyperthyroidism or pheochromocytoma; * History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension; * Intracranial tumor or neurosurgery; * Severe liver dysfunction (Child-Pugh class C), renal failure (requiring renal replacement therapy), or American Society of Anesthesiologists class IV or higher; * Enrolled in other clinical studies.