NCT06978712 Impact of Periodontal Inflammation on Allostatic Load
| NCT ID | NCT06978712 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Postgraduate Institute of Dental Sciences Rohtak |
| Condition | Allostatic Load |
| Study Type | INTERVENTIONAL |
| Enrollment | 112 participants |
| Start Date | 2025-06-10 |
| Primary Completion | 2026-06-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 112 participants in total. It began in 2025-06-10 with a primary completion date of 2026-06-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Periodontitis is a prevalent global health issue that contributes to systemic inflammation and is closely linked to stress as a risk factor. Both conditions have been investigated for bidirectional relationship. However, the results are inconsistent, and the mechanistic links remain unclear. Allostatic load, which measures the cumulative biological effects of stress, may be relevant in elucidating this connection. Inconsistent results have been reported in previous studies exploring the association between periodontitis and individual biomarkers of allostatic load. Furthermore, none of these studies has taken into consideration staging and grading of periodontitis. Additionally, while periodontal treatment has been shown to reduce both local and systemic inflammation, its effect on allostatic load remains unexplored till date. This study aims to fill these gaps by evaluating the relationship between these parameters of periodontitis and allostatic load. Evaluation of impact of subgingival instrumentation on allostatic load may further provide insights into the broader systemic benefits of periodontal interventions.
Eligibility Criteria
Inclusion Criteria: * Patients with age group 30-50 years diagnosed with generalized periodontitis. * Presence of minimum 20 teeth excluding third molars. Exclusion Criteria: * Periodontal treatment within last 6 months * History of antibiotic use within the previous 3 months * History of use of steroid, immunosuppressive and psychiatric drugs * Pregnant and lactating women * History of substance abuse
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06978712 clinical trial?
This trial is open to participants of all sexes, aged 30 Years or older, up to 50 Years, studying Allostatic Load. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06978712 currently recruiting?
Yes, NCT06978712 is actively recruiting participants. Contact the research team at rksharmamds@yahoo.in for enrollment information.
Where is the NCT06978712 trial being conducted?
This trial is being conducted at Rohtak, India.
Who is sponsoring the NCT06978712 clinical trial?
NCT06978712 is sponsored by Postgraduate Institute of Dental Sciences Rohtak. The trial plans to enroll 112 participants.