NCT07554326 Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
| NCT ID | NCT07554326 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ann & Robert H Lurie Children's Hospital of Chicago |
| Condition | Depressive Symptoms |
| Study Type | INTERVENTIONAL |
| Enrollment | 300 participants |
| Start Date | 2026-06-09 |
| Primary Completion | 2028-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 300 participants in total. It began in 2026-06-09 with a primary completion date of 2028-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
American youth and young adults face persistent and chronic stressors, which have contributed to a mental health crisis in the United States. Four in 10 American high school students experience chronic feelings of sadness and hopelessness, 2 in 10 report suicidal ideation, and 1 in 10 attempt suicide. For adolescents and young adults, chronic stress translates to weathering, or wear and tear on the mind and body. Chronic stress in youth contributes to psychological distress, elevated allostatic load, and an elevated risk for chronic diseases and premature death. While the connection between chronic stress and health is well documented, few studies provide evidence on innovative, non-medication strategies to reduce stress and mitigate the consequences of chronic stress on psychological and physiological outcomes. Thus, there is a critical need to rigorously test interventions that prevent the negative influence of chronic stress on mental and physical health, beginning in adolescence. The specific aims of the study are to 1) Determine whether a community-engagement, peer-based behavioral intervention reduces depressive symptoms in adolescents and young adults, 2) Determine whether a community-engagement behavioral intervention lowers allostatic load scores in adolescents and young adults, and 3) Identify factors that help sustain or inhibit community-engagement and intervention effects for adolescents and young adults. To accomplish these aims, the team will conduct a phase II community-engaged, peer group-based, multi-component randomized behavioral clinical trial. We will collect psychological and physiological measures at baseline, then at 6-month intervals for 2 years post-community-engaged, skills training.
Eligibility Criteria
Inclusion Criteria: 1. 15-20 years old 2. Identify as Black and/ or Hispanic/Latine 3. Speak English Exclusion Criteria: 1. Younger than 15 years old, or older than 20 years old 2. Unable to attend the in-person sessions 3. Non-fluent English speaker 4. Do not identify as Black or Hispanic/Latine
Contact & Investigator
Elan C Hope, PhD
PRINCIPAL INVESTIGATOR
Policy Research Associates
Frequently Asked Questions
Who can join the NCT07554326 clinical trial?
This trial is open to participants of all sexes, aged 15 Years or older, up to 20 Years, studying Depressive Symptoms. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07554326 currently recruiting?
Yes, NCT07554326 is actively recruiting participants. Contact the research team at nheardgarris@luriechildrens.org for enrollment information.
Where is the NCT07554326 trial being conducted?
This trial is being conducted at Chicago, United States.
Who is sponsoring the NCT07554326 clinical trial?
NCT07554326 is sponsored by Ann & Robert H Lurie Children's Hospital of Chicago. The principal investigator is Elan C Hope, PhD at Policy Research Associates. The trial plans to enroll 300 participants.