NCT06826365 Immune Cell Populations in the Endometrium
| NCT ID | NCT06826365 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Jagiellonian University |
| Condition | Infertility, Female |
| Study Type | OBSERVATIONAL |
| Enrollment | 50 participants |
| Start Date | 2025-07-01 |
| Primary Completion | 2026-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 50 participants in total. It began in 2025-07-01 with a primary completion date of 2026-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood. In ovulatory cycles, changes occur in the populations of uterine lymphocytes, which may influence the receptivity of the endometrium and the implantation of the embryo. Particularly notable are the changes in natural killer (NK) cells, which reach their peak during the luteal phase and regulate the invasion of the trophoblast. The dominant NK cells exhibit a CD56bright phenotype and differ in cytokine profiles from peripheral blood cells. Cyclical changes also affect macrophages and T lymphocytes; however, it is unclear whether their proportions differ in women with reduced fertility. There is a need to investigate how the composition of lymphocytes in blood influences the populations in the endometrium. The aim of this study is to analyze the correlation between peripheral and endometrial lymphocytes in women with idiopathic infertility and recurrent miscarriages, compared to fertile women.
Eligibility Criteria
Inclusion Criteria: * age 18-45 years * idiopathic infertility * at least 2 miscarriages * other benign gynecological conditions subjected to endometrial sampling Exclusion Criteria: * miscarriage within last 3 months * abdominal/uterine surgery within last 3 months * viral/bacterial infection within last 3 months * antibiotic therapy within last 3 months
Contact & Investigator
Kazimierz Pityński, Prof., PhD
STUDY CHAIR
Jagiellonian University
Frequently Asked Questions
Who can join the NCT06826365 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 45 Years, studying Infertility, Female. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06826365 currently recruiting?
Yes, NCT06826365 is actively recruiting participants. Contact the research team at iwona.gawron@uj.edu.pl for enrollment information.
Where is the NCT06826365 trial being conducted?
This trial is being conducted at Krakow, Poland.
Who is sponsoring the NCT06826365 clinical trial?
NCT06826365 is sponsored by Jagiellonian University. The principal investigator is Kazimierz Pityński, Prof., PhD at Jagiellonian University. The trial plans to enroll 50 participants.