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Recruiting NCT04014140

NCT04014140 iFR Guided Coronary Artery Bypass Grafting Surgery

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Clinical Trial Summary
NCT ID NCT04014140
Status Recruiting
Phase
Sponsor Prakash Punjabi
Condition Ischaemic Heart Disease
Study Type OBSERVATIONAL
Enrollment 100 participants
Start Date 2022-04-25
Primary Completion 2025-08-31

Eligibility & Interventions

Sex All sexes
Min Age 25 Years
Max Age 80 Years
Study Type OBSERVATIONAL
Interventions
Coronary artery bypass grafting surgery (CABG)

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 100 participants in total. It began in 2022-04-25 with a primary completion date of 2025-08-31.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

The expected outcome of better and improved patency of bypass grafts and its direct relation to pre-operative iFR measurements of stenosis as compared to direct visual physiology of stenosis in the coronary angiogram. To establish the correlation between the use of intracoronary physiology and improved graft patency at 12 months for patients undergoing CABG surgery. It is a minimum of 28 and a maximum of 100 patients single-centre proof or concept/ observational study/ pilot study.

Eligibility Criteria

INCLUSION CRITERIA 1. Age of 25 to 80 years of age 2. Willing to participate and able to understand, read and sign the informed consent form (ICF) before standard of care elective CABG surgery 3. Undergoing isolated first-time elective CABG surgery 4. Available pre-operative angiography data with iFR measurements done during the pre-operative angiography EXCLUSION CRITERIA 1. Emergency CABG surgery 2. Ejection Fraction≤ 40% 3. Severe valvular heart disease

Contact & Investigator

Central Contact

Prakash P Punjabi, MBBS,MCh,FRCS,FFST,FESC,FCCP

✉ P.Punjabi@imperial.ac.uk

📞 020 3313 2026

Principal Investigator

Prakash P Punjabi, MBBS,MCh,FRCS,FFST,FESC,FCCP

PRINCIPAL INVESTIGATOR

Imperial College Healthcare NHS Trust

Frequently Asked Questions

Who can join the NCT04014140 clinical trial?

This trial is open to participants of all sexes, aged 25 Years or older, up to 80 Years, studying Ischaemic Heart Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT04014140 currently recruiting?

Yes, NCT04014140 is actively recruiting participants. Contact the research team at P.Punjabi@imperial.ac.uk for enrollment information.

Where is the NCT04014140 trial being conducted?

This trial is being conducted at London, United Kingdom.

Who is sponsoring the NCT04014140 clinical trial?

NCT04014140 is sponsored by Prakash Punjabi. The principal investigator is Prakash P Punjabi, MBBS,MCh,FRCS,FFST,FESC,FCCP at Imperial College Healthcare NHS Trust. The trial plans to enroll 100 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology