NCT05718245 HEPA, PM2.5, and Cardiometabolic Health
| NCT ID | NCT05718245 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Southern California |
| Condition | Air Pollution |
| Study Type | INTERVENTIONAL |
| Enrollment | 52 participants |
| Start Date | 2023-03-15 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 52 participants in total. It began in 2023-03-15 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.
Eligibility Criteria
Inclusion Criteria: * Age between 65 and 84 years old; * Nonsmoker for at least 1 year; * History of BMI ≥ 25 kg/m2 in the past based on EMR information; * Either an English or Spanish speaker; * Live in the Los Angeles County. Exclusion Criteria: * History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia); * Currently have active cancer treatment; * The residential house has already had HEPA filters; * Participants will move out of the current house in the next 2 years; * Participants will spend more than one month living outside the primary home; * Have any health conditions that prohibit collecting health and covariate data and biospecimen; * The residential houses are not feasible for setting up air purifiers and air pollutants monitors; * Have high blood glucose from finger stick test (\> 200 mg/dL).
Contact & Investigator
Zhanghua Chen, PhD
PRINCIPAL INVESTIGATOR
University of Southern California
Frequently Asked Questions
Who can join the NCT05718245 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, up to 84 Years, studying Air Pollution. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05718245 currently recruiting?
Yes, NCT05718245 is actively recruiting participants. Contact the research team at zhanghuc@usc.edu for enrollment information.
Where is the NCT05718245 trial being conducted?
This trial is being conducted at Los Angeles, United States.
Who is sponsoring the NCT05718245 clinical trial?
NCT05718245 is sponsored by University of Southern California. The principal investigator is Zhanghua Chen, PhD at University of Southern California. The trial plans to enroll 52 participants.