NCT05867381 Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
| NCT ID | NCT05867381 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Southern California |
| Condition | Air Pollution |
| Study Type | INTERVENTIONAL |
| Enrollment | 112 participants |
| Start Date | 2023-07-11 |
| Primary Completion | 2028-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 112 participants in total. It began in 2023-07-11 with a primary completion date of 2028-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
Eligibility Criteria
Inclusion Criteria: * Age between 65 and 84 years old; * Weight ≥ 110 pounds; * Nonsmokers for at least 1 year; * Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records; * Both English and Spanish speaking participants will be included in the recruitment; * Live in the Los Angeles County. Exclusion Criteria: * Have history of degenerative disease of the nervous system such as dementia and Alzheimer's; * Currently have active cancer treatments; * The residential house has already had HEPA filters; * Participants will move out from the current residential address in the next 2 years; * Participants will spend more than 1 month living outside the primary home; * Have any health conditions that prohibit collecting health and covariate data and biospecimens; * Participants' residential houses are not feasible for setting up air purifiers and air pollutants monitors.
Contact & Investigator
Zhanghua Chen, PhD
PRINCIPAL INVESTIGATOR
University of Southern California
Frequently Asked Questions
Who can join the NCT05867381 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, up to 84 Years, studying Air Pollution. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05867381 currently recruiting?
Yes, NCT05867381 is actively recruiting participants. Contact the research team at zhanghuc@usc.edu for enrollment information.
Where is the NCT05867381 trial being conducted?
This trial is being conducted at Los Angeles, United States.
Who is sponsoring the NCT05867381 clinical trial?
NCT05867381 is sponsored by University of Southern California. The principal investigator is Zhanghua Chen, PhD at University of Southern California. The trial plans to enroll 112 participants.