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Recruiting Phase 1 NCT06069791

Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1

Trial Parameters

Condition Post-Traumatic Headache
Sponsor Yale University
Study Type INTERVENTIONAL
Phase Phase 1
Enrollment 12
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2024-01-26
Completion 2026-12-31
Interventions
Bupivacaine Injection

Brief Summary

The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will be randomized to receive three different concentrations, which will be injected one week apart each.

Eligibility Criteria

Inclusion Criteria: * United States Military Veterans within VA Connecticut Healthcare System * Chronic post-traumatic headache per ICHD-3 criteria (i.e., headaches are continuing to occur three months after the head injury) * At least two headache days per week * MRI brain scan completed within the past 3 months if chronic PTH for less than one year, within the past year if chronic PTH for less than 5 years, and within 5 years if chronic PTH for more than 10 years * Review of MRI and the medical record does not reveal another source for headache Exclusion Criteria: * Skull defect * Other contraindication to bupivacaine 1. Allergy or adverse reaction (e.g., rash, cardiac effects) to amide anesthetics, such as lidocaine 2. Instruction from clinician to avoid amide anesthetics, such as lidocaine * Pregnant or lack of adequate birth control

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