NCT06948149 Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
| NCT ID | NCT06948149 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Western University, Canada |
| Condition | Creatine |
| Study Type | INTERVENTIONAL |
| Enrollment | 200 participants |
| Start Date | 2026-01-01 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 200 participants in total. It began in 2026-01-01 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function in older adults with mild cognitive impairment. Previous studies have shown that resistance training improves cognition and brain health in older adults. Creatine is naturally occurring in the human body and is known to decline with age. Studies have shown that creatine increases muscle mass and bone density in older adults when supplemented. Some research has suggested that creatine may also improve cognition and brain health. However, little is known about how creatine supplementation affects the aging brain and body alone and when combined with resistance training, especially in those with known cognitive impairment. In this study, participants will be randomly assigned to one of four groups: 1) creatine and resistance training, 2) placebo and resistance training, 3) creatine and active control (balance and tone classes), or 4) placebo and active control. Participants in the creatine groups will take creatine every day during the study. Participants in the placebo groups will take a look-alike substance that contains no drug every day during the study. Participants in the resistance training groups will attend three 60-minute classes per week that target each major muscle group and will increase in difficulty during the study. Participants in the active control group will attend three 60-minute classes per week that will consist of balance, stretching, and range of motion exercises. This group accounts for variables such as physical training received by traveling to the training centres, social interaction, and changes in lifestyle secondary to study participation. Researchers will collect information before and after the 26 weeks to see if creatine supplementation and/or resistance training have any effects on cognition, brain health, and/or physical function. The investigators suspect that both creatine supplementation and resistance training will improve cognition, brain health, and physical function alone. However, it is thought that the combination of creatine supplementation and resistance training will improve cognition, brain health, and physical function more.
Eligibility Criteria
To be eligible to participate in this study participants must: 1. be 60 years of age or older, 2. live independently in the community, 3. have normal or corrected-to-normal vision and hearing, 4. read, write, and speak English fluently, 5. be right-handed, 6. have subjective feelings of memory decline in the past 5 years, 7. have MoCA scores 19-25/30 (assessed at baseline session), 8. be able to exercise at a moderate pace using resistance training for 60 minutes 3x/week, 9. receive clearance from a physician to participate in an exercise program, and 10) receive confirmation from a physician that they meet all criteria to be included in this study. Participants are ineligible if they: 1. cannot partake or commit to exercise training 3x/week for 26 weeks or have regularly (\>1x/week) engaged in exercise training over the past 3 months; 2. cannot partake or commit to consuming a daily supplement for 26 weeks or consumed nutritional supplements containing creatine monohydrate over the past 3 months; 3. have a known allergy to creatine monohydrate or dextrose; 4. have been diagnosed with a neurological disorder (e.g., Alzheimer's disease, Parkinson's disease); 5. have pre-existing kidney disease, heart disease, or liver abnormalities; 6. have one or more uncontrolled chronic or psychiatric conditions (e.g., hypertension, diabetes, depression, anxiety); 7. are taking medication that may impact kidney function (e.g., non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen); or 8. are ineligible or uncomfortable with MRI (have metal or electronic implants, claustrophobia) or blood sampling.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06948149 clinical trial?
This trial is open to participants of all sexes, aged 60 Years or older, studying Creatine. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06948149 currently recruiting?
Yes, NCT06948149 is actively recruiting participants. Contact the research team at lnagamat@uwo.ca for enrollment information.
Where is the NCT06948149 trial being conducted?
This trial is being conducted at London, Canada.
Who is sponsoring the NCT06948149 clinical trial?
NCT06948149 is sponsored by Western University, Canada. The trial plans to enroll 200 participants.