| NCT ID | NCT06107842 |
| Status | Recruiting |
| Phase | — |
| Sponsor | VA Office of Research and Development |
| Condition | Aging |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2024-04-01 |
| Primary Completion | 2028-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 150 participants in total. It began in 2024-04-01 with a primary completion date of 2028-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Over 50% of the Veterans enrolled for VA health care are over the age of 65. Dementia prevalence increases with age, and with the increase in the population of people ages 65 and older, the total number of people with dementia is also increasing. Older Veterans often have comorbid PTSD, major depression and traumatic brain injury so that they are at 2 to 5 times the risk for cognitive impairment and dementia compared to the general population. There is evidence that exercise interventions in sedentary older adults could improve both physical and cognitive function. However, there have been very few studies on the effects of exercise on cognition in older Veterans and do not reflect the broader ethnic and health-status diversity of Veterans. Thus, improved knowledge of the role of exercise on cognition as well as the predictive power of biomarkers could have a major beneficial impact on Veterans' functional independence and quality of life. The investigators hypothesize that participation in the VA Gerofit exercise program will improve cognitive function in older Veterans and that blood and muscle biomarkers will predict these improvements.
Eligibility Criteria
Inclusion Criteria: * All Veterans eligible for VA Gerofit program 65 years and older * Clearance by PCP to participate in Gerofit exercise program Exclusion Criteria: * Inability to perform ADLs * Significant cognitive impairment * Inability to function independently without assistance * Unstable angina; proliferative diabetic retinopathy * Oxygen dependent * Unwillingly to commute and/or not able to provide own transportation to Gerofit * Incontinence * Open wounds * Volatile behavioral issue or unable to work successfully in a group environment/setting * Active substance abuse * Homelessness
Contact & Investigator
Cathy C Lee, MD
PRINCIPAL INVESTIGATOR
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
Frequently Asked Questions
Who can join the NCT06107842 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, studying Aging. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06107842 currently recruiting?
Yes, NCT06107842 is actively recruiting participants. Contact the research team at cathy.lee2@va.gov for enrollment information.
Where is the NCT06107842 trial being conducted?
This trial is being conducted at West Los Angeles, United States, Baltimore, United States.
Who is sponsoring the NCT06107842 clinical trial?
NCT06107842 is sponsored by VA Office of Research and Development. The principal investigator is Cathy C Lee, MD at VA Greater Los Angeles Healthcare System, West Los Angeles, CA. The trial plans to enroll 150 participants.