NCT06906276 Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes
| NCT ID | NCT06906276 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Karolinska Institutet |
| Condition | Gait Disorders, Neurologic |
| Study Type | OBSERVATIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-03-14 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 30 participants in total. It began in 2025-03-14 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as atypical Parkinson's disease (APD) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions. The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecologically valid state. The investigators aim therefore to explore brain function during complex walking in healthy and APD by investigating the effects of age and neurological disease on motor-cognitive performance and its neural correlates during three conditions of complex walking (dual-task walking, navigation and a combination of both) using non-invasive measures of brain activity (functional near infrared spectrometry, fNIRS) and advanced gait analysis in real time in older healthy adults and people with APD.
Eligibility Criteria
Inclusion Criteria: * clinical diagnosis of PSP according to Movement Disorder Society (MDS) (2017) or * MSA according to MDS criteria (2022) * the ability to walk with or without a mobility device for ≤5 minutes continuously Exclusion Criteria: * cognitive difficulties affecting the ability to understand and/or follow verbal/written - instructions * severe freezing of gait * Severe hearing or visual impairments that affect participation in the assessments * Other neurological diseases * Other diseases that can affect gait or balance.
Contact & Investigator
Franziska Albrecht, PhD
PRINCIPAL INVESTIGATOR
Karolinska Institutet
Frequently Asked Questions
Who can join the NCT06906276 clinical trial?
This trial is open to participants of all sexes, studying Gait Disorders, Neurologic. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06906276 currently recruiting?
Yes, NCT06906276 is actively recruiting participants. Contact the research team at compliance@ki.se for enrollment information.
Where is the NCT06906276 trial being conducted?
This trial is being conducted at Solna, Sweden.
Who is sponsoring the NCT06906276 clinical trial?
NCT06906276 is sponsored by Karolinska Institutet. The principal investigator is Franziska Albrecht, PhD at Karolinska Institutet. The trial plans to enroll 30 participants.