This study aims to understand how genetics and the immune system work together to cause type 1 diabetes. Researchers will analyze blood samples to identify the step-by-step process that leads to diabetes development. This knowledge could help improve prevention and treatment strategies in the future.
Key Objective: The trial seeks to identify genetic and immune system factors that trigger type 1 diabetes, which could lead to better prevention and early intervention strategies.
Who to Consider: People with type 1 diabetes or those with a family history of type 1 diabetes who are interested in contributing to genetic research should consider enrolling.
Trial Parameters
Brief Summary
The purpose of this study is to gain more information about the step-by-step process that causes someone to develop type 1 diabetes. Scientists think that a person's own immune system, directed by genetic and environmental factors play a major role in its development. Participation involves a blood draw, a brief medical history questionnaire and measurements of height and weight. Some participants will be asked to return for annual follow-up visits for 10 years.
Eligibility Criteria
Inclusion Criteria (Families): * Families where at least one first-degree family member has type 1 diabetes * The diabetic proband in the family was diagnosed before the age of 39 * Family members must be at least 2 years old to participate Exclusion Criteria (Families): * Families with no history of type 1 diabetes * Families with a history of diabetes that is not type 1 (LADA, MODY, type 2 etc.) Inclusion Criteria (Controls): * No family history of type 1 diabetes or other autoimmune conditions * Age 2 or older Exclusion Criteria (Controls): * Personal or family history of autoimmune disease