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Medical Condition
diabetes mellitus type 1
Total Trials
13
Recruiting Now
13
Trial Phases
Phase 4, EARLY_Phase 1, Phase 2
Diabetes clinical trials span both type 1 (autoimmune beta-cell destruction) and type 2 (insulin resistance) disease, with growing focus on the overlapping spectrum including latent autoimmune diabetes in adults (LADA) and monogenic forms. Research priorities include beta-cell preservation in newly diagnosed type 1 patients, weight-loss-independent glucose control, and prevention of cardiovascular and renal complications.
Current trials evaluate GLP-1/GIP dual agonists (tirzepatide analogs), oral insulin formulations, closed-loop artificial pancreas systems, immunotherapy for type 1 delay, SGLT2 inhibitors in non-diabetic heart failure, and stem-cell-derived islet transplantation. Lifestyle intervention trials also remain an active category.
Many trials separate type 1 and type 2 cohorts; baseline HbA1c, duration of disease, and eGFR are common eligibility criteria.
Frequently Asked Questions — diabetes mellitus type 1 Clinical Trials
How many clinical trials are currently recruiting for diabetes mellitus type 1?
ClinicalMetric currently tracks 13 actively recruiting clinical trials for diabetes mellitus type 1, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 13. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for diabetes mellitus type 1?
diabetes mellitus type 1 research spans Phase 1 (2 trials), Phase 2 (2 trials), Phase 3 (1 trial), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a diabetes mellitus type 1 clinical trial?
Eligibility criteria for diabetes mellitus type 1 trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1 2
Phase 2 2
Phase 3 1
Phase 4 1
Top Sponsors
2 trials
1 trial
1 trial
1 trial
1 trial
Recruiting Clinical Trials
NCT06807190
Recruiting
General Use-results Surveillance With Awiqli in Patients With Diabetes Mellitus
Enrollment
630 pts
Location
Japan
Sponsor
Novo Nordisk A/S
NCT04629586
Recruiting
The T1D Exchange Registry
Enrollment
50,000 pts
Location
United States
Sponsor
T1D Exchange, United States
NCT05585983 Phase 4
Recruiting
INfluenza VaccInation To Mitigate typE 1 Diabetes
Enrollment
100 pts
Location
Denmark
Sponsor
Aarhus University Hospital
NCT05317455 EARLY_Phase 1
Recruiting
Regulation of Brain Glucose Metabolism in Type 1 Diabetes
Enrollment
16 pts
Location
United States
Sponsor
Yale University
NCT07386340
Recruiting
Gemini Study: A Prospective, Multicenter Evaluation of Performance and Safety of the Eversense Gemini System With Flash Glucose Measurement Feature
Enrollment
80 pts
Location
United States
Sponsor
Senseonics, Inc.
NCT06688331 Phase 2
Recruiting
Treatment of Presymptomatic (Stage 1) Type 1 Diabetes Pediatric Patients With Treg Cell Preparations and Anti-CD20 Antibody
Enrollment
150 pts
Location
Poland
Sponsor
PolTREG S.A.
NCT01055093
Recruiting
Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients
Enrollment
2,000 pts
Location
Germany
Sponsor
German Diabetes Center
NCT07160816
Recruiting
A Research Study to See How Insulin Icodec Helps People With Type 1 Diabetes Control Their Blood Sugar
Enrollment
245 pts
Location
Germany, Italy
Sponsor
Novo Nordisk A/S
NCT05626712 Phase 1, Phase 2
Recruiting
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Enrollment
18 pts
Location
United States
Sponsor
Creative Medical Technology Ho...
NCT05286892
Recruiting
Diabetes Learning in Virtual Environments Just in Time for Community Reentry
Enrollment
128 pts
Location
United States
Sponsor
Louise Reagan
NCT04786262 Phase 3
Recruiting
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Enrollment
52 pts
Location
United States, Canad...
Sponsor
Vertex Pharmaceuticals Incorpo...
NCT03648918
Recruiting
Genetics Of Autoimmunity In Type I Diabetes
Enrollment
4,000 pts
Location
United States
Sponsor
Medical College of Wisconsin
NCT00097292
Recruiting
TrialNet Pathway to Prevention of T1D
Enrollment
75,000 pts
Location
United States, Austr...
Sponsor
University of South Florida
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology