NCT07662291 Frequency Effects of Transcutaneous Trigeminal Nerve Stimulation (eTNS) on Brain and Autonomic Function
| NCT ID | NCT07662291 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Xidian University |
| Condition | Healthy Volunteers |
| Study Type | INTERVENTIONAL |
| Enrollment | 25 participants |
| Start Date | 2026-08-06 |
| Primary Completion | 2026-08-20 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 25 participants in total. It began in 2026-08-06 with a primary completion date of 2026-08-20.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to investigate how different frequencies of transcutaneous Trigeminal Nerve Stimulation (eTNS) affect brain activity and the autonomic nervous system in healthy individuals. Participants will undergo a 3T functional magnetic resonance imaging (fMRI) scan while receiving three different types of nerve stimulation: 2Hz eTNS, 120Hz eTNS, and a sham (inactive) stimulation. The order of these stimulations will be randomly assigned. During the brain scan, researchers will simultaneously monitor the participants' breathing and heart rhythms (using a finger sensor). The main goal is to understand how changing the frequency of eTNS influences the connection between the brain's networks and the body's unconscious physiological responses.
Eligibility Criteria
Inclusion Criteria: 1. Healthy volunteers, aged 18 to 40 years old. 2. Right-handed. 3. Generally healthy with no history of neurological, psychiatric, or severe cardiovascular diseases. 4. Normal physical and neurological examinations. 5. Capable of understanding the study procedures and voluntarily signing the written informed consent form. Exclusion Criteria: 1. Contraindications to MRI scanning (e.g., claustrophobia, cardiac pacemakers, artificial cochlea, metallic braces, or any other ferromagnetic implants). 2. Female participants who are pregnant, lactating, or suspect they might be pregnant. 3. Contraindications to transcutaneous electrical stimulation (e.g., personal or family history of epilepsy/seizures, trigeminal neuralgia, facial skin lesions, or active skin diseases on the forehead). 4. Current or recent (within the past month) use of any medications known to affect the central nervous system or the autonomic nervous system (e.g., antidepressants, beta-blockers, sedatives, or sympathomimetics). 5. History of substance abuse, heavy smoking, or excessive daily consumption of alcohol or caffeine. 6. Irregular sleep patterns, shift work, or severe sleep deprivation within 24 hours prior to the scanning session.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07662291 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 35 Years, studying Healthy Volunteers. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07662291 currently recruiting?
Yes, NCT07662291 is actively recruiting participants. Contact the research team at xjyang@xidian.edu.cn for enrollment information.
Where is the NCT07662291 trial being conducted?
This trial is being conducted at Xi'an, China.
Who is sponsoring the NCT07662291 clinical trial?
NCT07662291 is sponsored by Xidian University. The trial plans to enroll 25 participants.