Trial Parameters
Brief Summary
Study will utilize an app, Matter Neuroscience, designed to help users with depression understand positive emotions and the neurotransmitters that create them. We hope to learn the safety and efficacy of neurofeedback for treating depression and lay the groundwork for a pivotal clinical trial.
Eligibility Criteria
Inclusion Criteria: 1. Male or Female, between the ages of 18 and 80 at the time of screening. 2. Primary diagnosis of nonpsychotic major depressive disorder (MDD) without a history of psychotic features. 3. Score on the MADRS scale between 15-25 4. Able to read, understand, and provide written, dated informed consent prior to screening. Proficiency in English sufficient to complete questionnaires / follow instructions during fMRI. Stated willingness to comply with all study procedures, including availability for the duration of the study, and to communicate with study personnel about adverse events and other clinically important information. 5. Must possess an iPhone with the latest iOS version compatible with the app, and be capable of using the study app with the phone. 6. 1-5 lifetime adequate antidepressant medication failures (ATHF). 7. The dose of the primary antidepressant medication (if applicable) must be stable for 4 weeks prior to baseline, and participants must agree to co