NCT05558345 Expression of Stress Markers During Meth Treatment (EXPRESS+)
| NCT ID | NCT05558345 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, Los Angeles |
| Condition | Substance-Related Disorders |
| Study Type | INTERVENTIONAL |
| Enrollment | 55 participants |
| Start Date | 2022-09-01 |
| Primary Completion | 2025-03-31 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This is a non-randomized behavioral trial that aims to investigate whether changes in inflammatory and type I IFN expression coincide with changes in methamphetamine use and viral load over the course of 12 weeks in HIV-positive people assigned male at birth with and without methamphetamine use disorder.
Eligibility Criteria
Inclusion Criteria: For Contingency Management: 1. Assigned male sex at birth 2. 18 to 45 years of age 3. Reports having sex with men in the past 12 months. 4. HIV-positive (confirmed by certification or by HIV rapid test) 5. Has an HIV care provider (last seen in the past 12 months) 6. Has a current antiretroviral prescription 7. Meets the DSM-5 criteria for methamphetamine use disorder using SCID-5 8. Urine test is positive for methamphetamine within 30 days of their screening visit 9. Seeking treatment for methamphetamine use disorder. 10. Ability to attend twice weekly appointments for drug testing and treatment For Non-substance-using Control: 1. Assigned male sex at birth 2. 18 to 45 years of age 3. Reports having sex with men in the past 12 months. 4. HIV-positive (confirmed by certification or by HIV rapid test) 5. Has an HIV care provider (last seen in the past 12 months) 6. Has a current antiretroviral prescription Exclusion Criteria: For Contingency Management: 1. Identifies