Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy
Trial Parameters
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Brief Summary
The goal of this observational study is to learn how exercise training affects molecular processes in skeletal muscle in adults with mitochondrial myopathy, compared with healthy adults. The main questions it aims to answer are: * How does exercise training affect mitochondrial activity and energy production pathways in skeletal muscle in people with mitochondrial myopathy? * How does exercise training affect molecular signals related to muscle growth, stress responses, and muscle-nerve communication in people with mitochondrial myopathy? Researchers will compare the trained leg to the untrained leg within the same participant, and also compare responses between participants with mitochondrial myopathy and healthy control participants, to see how molecular responses to exercise differ between groups. The participants will: * Complete a 3-4-week supervised exercise training program using one leg. * Undergo muscle biopsies from both the trained and untrained leg. * Complete basic muscle strength and physical function tests.
Eligibility Criteria
Eligibility criteria for Mitochondrial Myopathy-group: Inclusion Criteria * Known mtDNA or nuclear (nDNA) mutations * Age above or equal to 18 years Exclusion Criteria: * Medical conditions which deem the MM patient unfit to complete the study * Current use of medications known to interact with outcome measures. (see below) * Pregnancy * The participant is for any other reason unlikely to complete the study Inclusion Criteria for healthy controls * Age above or equal to 18 years Exclusion Criteria: * Chronic medical conditions suspected to influence outcome measures * Frequent use of medicine * Pregnancy * The participant is for any other reason unlikely to complete the study