NCT07450690 Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy
| NCT ID | NCT07450690 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Copenhagen |
| Condition | Mitochondrial Diseases |
| Study Type | INTERVENTIONAL |
| Enrollment | 22 participants |
| Start Date | 2026-01-09 |
| Primary Completion | 2026-10-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 22 participants in total. It began in 2026-01-09 with a primary completion date of 2026-10-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to learn how exercise training affects molecular processes in skeletal muscle in adults with mitochondrial myopathy, compared with healthy adults. The main questions it aims to answer are: * How does exercise training affect mitochondrial activity and energy production pathways in skeletal muscle in people with mitochondrial myopathy? * How does exercise training affect molecular signals related to muscle growth, stress responses, and muscle-nerve communication in people with mitochondrial myopathy? Researchers will compare the trained leg to the untrained leg within the same participant, and also compare responses between participants with mitochondrial myopathy and healthy control participants, to see how molecular responses to exercise differ between groups. The participants will: * Complete a 3-4-week supervised exercise training program using one leg. * Undergo muscle biopsies from both the trained and untrained leg. * Complete basic muscle strength and physical function tests.
Eligibility Criteria
Eligibility criteria for Mitochondrial Myopathy-group: Inclusion Criteria * Known mtDNA or nuclear (nDNA) mutations * Age above or equal to 18 years Exclusion Criteria: * Medical conditions which deem the MM patient unfit to complete the study * Current use of medications known to interact with outcome measures. (see below) * Pregnancy * The participant is for any other reason unlikely to complete the study Inclusion Criteria for healthy controls * Age above or equal to 18 years Exclusion Criteria: * Chronic medical conditions suspected to influence outcome measures * Frequent use of medicine * Pregnancy * The participant is for any other reason unlikely to complete the study
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07450690 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Mitochondrial Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07450690 currently recruiting?
Yes, NCT07450690 is actively recruiting participants. Contact the research team at tue.leth.nielsen.01@regionh.dk for enrollment information.
Where is the NCT07450690 trial being conducted?
This trial is being conducted at Copenhagen, Denmark.
Who is sponsoring the NCT07450690 clinical trial?
NCT07450690 is sponsored by University of Copenhagen. The trial plans to enroll 22 participants.