NCT06607913 Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength

Trial Parameters

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Brief Summary

The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.

Eligibility Criteria

Inclusion Criteria: * Age \> 55 years * Diagnosis of stage 3-4 CKD or an eGFR of \<45 mL/min/1.73m2 Exclusion Criteria: * Cardiovascular risk: Poorly controlled hypertension (\>160/100) * Coronary event in past 6 months * Class III or IV CHF * symptomatic angina at rest or during exercise * Syncope in past year, without known resolution of cause * COPD requiring home oxygen * Contraindications to resistance training, including history of intracranial or retinal bleeding; Diabetes with active proliferative retinopathy * History of significant spinal osteoarthritis or spinal stenosis * Dementia (on medical record review or mini-mental status exam score)

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