Evaluation of the Electronic Cigarette Withdrawal Syndrome
Trial Parameters
Brief Summary
The goal of this project is to rigorously evaluate the nature of e-cigarette withdrawal in exclusive e-cigarette users during a monitored abstinence period and the role of nicotine in the expression of this withdrawal syndrome.
Eligibility Criteria
Inclusion criteria: 1. 21-55 years old 2. good general health as reviewed by study medical team 3. vital signs in normal range as reviewed by study medical team 4. negative urine test for illicit drug use (excluding THC) and negative breath alcohol test 5. daily use of a nicotine-containing e-cigarette for at least 6 months 6. no regular use of other tobacco products (e.g., smokeless products) for at least 6 months 7. urine cotinine \>100ng/mL (i.e., recommended cutoff for confirming current nicotine use) 8. exhaled breath carbon monoxide (CO) \<6ppm 9. Penn State E-cigarette Dependence (PSED) score \>=4, indicating mild dependence or greater 10. have an interest in reducing e-cigarette use Exclusion criteria: 1. psychoactive drug use (aside from cannabis, nicotine, alcohol, caffeine) in past month 2. current use of over-the-counter (OTC) or prescription medications that may impact safety 3. use cannabis \>2 times per week 4. history of or current significant medical condition that wou