NCT06971848 Evaluation of Skin Tests in Biotherapy Allergies
| NCT ID | NCT06971848 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Angers |
| Condition | Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck |
| Study Type | INTERVENTIONAL |
| Enrollment | 70 participants |
| Start Date | 2026-06-17 |
| Primary Completion | 2028-06 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 70 participants in total. It began in 2026-06-17 with a primary completion date of 2028-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Biotherapies are biological (extracted from an organism or living tissue) or biotechnological drugs used in the treatment of multiple conditions, such as autoimmune inflammatory diseases, cancers, and hematologic diseases. In recent years, these biotherapies have notably emerged in the treatment of cancers and hematologic disorders. As such, most patients with cancers or hematologic diseases will likely receive a biotherapy as part of their care pathway. These biotherapies are associated with various side effects, including hypersensitivity or allergic reactions, which are often poorly characterized in clinical trials. These reactions manifest as symptoms without specific dermatologic or allergologic semiology (such as itching, erythema, shortness of breath, sometimes digestive issues, or discomfort, and in some cases, an anaphylactic reaction). Unlike other treatments, such as antibiotics and neuromuscular blockers, there are currently no guidelines on the concentrations to use in skin tests for biotherapies. We propose conducting prospective clinical research to scientifically establish the concentrations to be used when investigating hypersensitivity to a biotherapy, in line with best practice recommendations for drug skin testing.
Eligibility Criteria
Inclusion Criteria : * Patient treated with one of the biotherapies under study (Atezolizumab 1200 mg, Nivolumab 480 mg, Obinutuzumab 100 mg, Durvalumab 1500 mg, Pembrolizumab 200 mg, Daratumumab 1800 mg, Cemiplimab 3500 mg) and who has received at least two injections of the biotherapy without suspected allergic side effects. * Subjects covered by or having the rights to medical care assurance * Written informed consent obtained from subject * If applicable, treatment with corticosteroids and H1 antihistamines by systemic route (IV or oral) which may be discontinued at least one week before performing the tests (Inhaled corticosteroids are allowed). Exclusion Criteria: * Presence of local or diffuse dermatological lesions (e.g., psoriasis, eczema, ...) that could interfere with the interpretation of skin tests. * Poor understanding of the French language * Pregnancy, breastfeeding * Persons in detention by judicial or administrative decision * Person admitted to a health or social establishment for purposes other than research * Person subject to a legal protection measure
Contact & Investigator
Martine MORISSET
PRINCIPAL INVESTIGATOR
University Hospital, Angers
Frequently Asked Questions
Who can join the NCT06971848 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06971848 currently recruiting?
Yes, NCT06971848 is actively recruiting participants. Contact the research team at martine.morisset@chu-angers.fr for enrollment information.
Where is the NCT06971848 trial being conducted?
This trial is being conducted at Angers, France.
Who is sponsoring the NCT06971848 clinical trial?
NCT06971848 is sponsored by University Hospital, Angers. The principal investigator is Martine MORISSET at University Hospital, Angers. The trial plans to enroll 70 participants.